What is CBD? The world's most researched non-psychoactive cannabinoid

CBD (Cannabidiol)is found in the cannabis plant (Cannabis sativa)One of over 100 cannabinoidsIt is currently the most researched and widely used cannabinoid in the world.Non-psychoactiveHowever, due to its potential for a wide range of physiological effects, it is attracting attention worldwide in the fields of medicine, wellness, and beauty.

CBD was first isolated and identified in the 1940s and in 1963 by Israeli chemistsDr. Raphael MechoulamIts chemical structure was completely elucidated by researchers at the University of California, San Diego, and others. It has the longest history of research compared to other cannabinoids.In 2018, the US FDA (Food and Drug Administration) officially approved Epidiolex®, a prescription drug containing pure CBD as the world's first CBD drug.This approval marks a historic milestone, marking one of the biggest turning points in the history of cannabinoid research, as a national agency has officially recognized the scientific efficacy of CBD in the treatment of intractable epilepsy.

A critical review published in 2018 by the World Health Organization (WHO) Expert Committee on Drug Dependence (ECDD) concluded that CBD"Generally well tolerated with a good safety profile"It was concluded thatNo abuse risk or dependency observedIt has also been confirmed.

The mechanism by which CBD is produced – the biosynthetic process

Unlike CBN, CBD is not a breakdown product of THC, but rather a product of the plant's growth process.Direct enzymatic biosynthesisAs the cannabis plant matures, CBGA is converted and then converted into the active form, CBD, by heating and decarboxylation.

Industrial hemp contains CBDMaximum around 20%The CBD content of hemp has been improved, and most of the CBD products currently on the market are derived from hemp.THC content 0.3% or less (US standards)This refers to a method that allows CBD to be efficiently extracted from the whole plant.

What's the difference between CBD, CBG, CBN, and THC? - Comparison Chart

CBD is one of the cannabinoidsThe most extensive researchIt is the only cannabinoid for which there is an FDA-approved drug (Epidiolex®). Understanding how it differs from other major cannabinoids is the first step in choosing the right product for you.

The Endocannabinoid System (ECS) and CBD

CBD isEndocannabinoid System (ECS)CBD acts on the CB1 and CB2 receptors through a unique approach that differs from THC and CBN.Functions as a negative allosteric modulator of the receptorCBD indirectly regulates various pathways, such as suppressing excessive activation caused by THC. This is one of the reasons why CBD is said to "mitigate the effects of THC."

このMulti-target and indirect mechanism of actionThis is a major feature of CBD, and is said to be the reason why it has few side effects and can potentially treat a wide range of conditions.PMCThe published review (Bergamaschi et al.) analyzed 132 original studies and found that:CBD has neuroprotective antioxidant properties that surpass those of vitamins C and EIt has also been reported to show

CBD's notable properties and research trends

The following is a summary of the major ongoing and published studies: CBD compared to CBG and CBNThe vast majority of human clinical trials have been conductedIn some areas, scientific evidence at the pharmaceutical level has been accumulated.Research stageAlthough it includes other ingredients, it can be said that it has the most scientific evidence of the three ingredients.

What do global experts and research institutes think about CBD?

He is a lecturer at Harvard Medical School and a cannabis specialist at Massachusetts General Hospital.Peter Grinspoon MDwrote in a Harvard Health Publishing article:The strongest scientific evidence for the health benefits of CBD is in the treatment of childhood epilepsies, including Dravet syndrome and Lennox-Gastaut syndrome. It has also been shown to be useful for anxiety, insomnia, and chronic pain in animal and human studies. While more research is needed, CBD is beginning to show promise as a useful, relatively non-toxic option for these conditions.. "

Neuroscientist and Director of the Addiction Research Institute at Mount Sinai Hospital (USA)Yasmin Hurd, PhDIs "We hope that within the next few years we will have concrete information on optimal administration protocols for specific symptoms and conditions, which is essential for evidence-based use." He expressed great expectations for the results of the ongoing drug craving research.

WHO (World Health Organization) Expert Committee on Drug Dependence (ECDD)In a critical review in 2018, the authors wrote about CBD:No risk of addiction or abuse" and concluded that "physical dependence and withdrawal symptoms have not been confirmed in either animal or human tests.""Generally well tolerated with a good safety profile"This is widely cited as the basis for countries to consider deregulating it as a pharmaceutical.

CBD Safety Profile – Side Effects and Precautions

A large body of literature supports the good safety profile of CBD, including a review by Bergamaschi et al. that pooled and analyzed 132 original studies.Doses up to 1,500 mg per day have been repeatedly tolerated in humansHowever, you should be aware of the following points:

The main forms of CBD products and how to choose them

Of all cannabinoids, CBD is available in the most diverse product forms on the market. Since the rate of absorption and bioavailability vary greatly depending on the route of administration, it is important to choose the right one for your purpose.

When choosing a product, we recommend checking the following points:

• COA (Certificate of Analysis / Third-Party Inspection Certificate)Is it published?
• THC content below standard limitsHas it been proven to be
• Is the CBD content (mg) accurately labeled? (A JAMA study found significant discrepancies between the labeled and actual CBD content in commercially available CBD products.)
• Are tests carried out for pesticides, heavy metals, and residual solvents?
• Is the distinction between full spectrum, broad spectrum, and isolate clear?

CBD, CBG, and CBN: A guide to choosing the right one for your needs

Legal Status of CBD (Regulations in Japan)

As of January 2024, CBD is not regulated in Japan.Japan's Cannabis Control Act and Narcotics and Psychotropic Substances Control Act regulate psychoactive ingredients such as THC.CBD that does not contain THC (or has a THC content below the standard limit) can be legally distributed, sold, and used..

However, with the amendment of the Cannabis Control Act in 2023, legal interpretations regarding the "regulation of cannabis-derived ingredients" are being clarified.Always check the latest legal informationWe strongly recommend that you always read the following before purchasing a product.Products from trusted manufacturers that are THC-free and certified with a COAplease choose.