What is CBG? A rare compound known as the "mother of all cannabinoids"

CBG (Cannabigerol)is found in the cannabis plant (Cannabis sativa)One of over 100 cannabinoidsIt is called the "Mother of All Cannabinoids." The reason is that:CBGA (cannabigerolic acid), the acidic precursor of CBG, is the starting point for the biosynthesis of major cannabinoids such as CBD, THC, and CBC.As the plant matures, CBGA is converted into other cannabinoids, and ultimately, only a small amount of CBG remains in the fully ripe plant.1% or lessThis rarity is one of the major features of CBG.

CBG was discovered in 1964 by Israeli chemistsDr. Raphael MechoulamSince then, it has been hidden in the shadows of research as a "minor cannabinoid," but with the accumulation of scientific knowledge in recent years,The next hot topic after CBDIt is attracting the attention of researchers and clinicians around the world.

The mechanism of CBG production – the biosynthetic process

CBGA, the precursor to CBG, is produced in the plant.Geranyl diphosphate (GPP) and olivetolic acidThe enzyme CBGA synthase combines these two compounds to produce CBGA. As the plant grows, CBGA is converted into each cannabinoid in the process shown below.

There is very little CBG left in the mature plant.To extract CBG efficiently, use young cannabis plants (approximately 6 weeks after flowering).In recent years, varieties that have been bred to have a high CBG content have been developed.CBG-specific hemp varietiesCultivation of this plant is also progressing.

What's the difference between CBG, CBD, and THC? - Comparison Chart

CBG, like CBD,Non-psychoactiveHowever, due to differences in molecular structure, their mechanisms of action in the body and expected properties differ.

The Endocannabinoid System (ECS) and CBG

CBG in the bodyEndocannabinoid System (ECS)The ECS is a cell signaling system discovered in the early 1990s.Sleep, mood, appetite, pain, immune response, memoryCBG acts through the ECS in the following ways:

like thisMulti-target actionThis is why CBG is attracting attention in a variety of research fields.Frontiers in PharmacologyA review article published in (2025) concluded that CBG isPotential antioxidant, anti-inflammatory, neuroprotective, antibacterial, and anti-cancer effects comparable to those of vitamin EIt has been reported to indicate "

CBG's notable properties and research trends

The following is a summary based on major ongoing and published studies.Research stageAlthough we do not assert that it has any medical effects, we would like to introduce the latest scientifically based findings.

What do global experts think about CBG?

Interest in CBG is not limited to consumers; it is also growing among the world's leading cannabinoid researchers.

A neurologist and researcher known as a leading expert in cannabinoid medicineEthan Russo, MDIn an interview with Project CBD, he spoke about the potential of CBG:CBG has enormous potential. It is non-psychoactive, has powerful anti-anxiety properties, and may be a powerful antibacterial agent effective against resistant bacteria like MRSA, which are resistant to standard antibiotics." . Dr. Russo, who participated as a co-researcher in the 2024 WSU study (Cuttler et al.), commented on the results:It is groundbreaking that the anti-anxiety effect was confirmed with just 5% of the required dose of CBD." he also said.

Associate Professor of Psychology at Washington State University (WSU)Carrie CuttlerDr. Ito led the first-ever human clinical trial of CBG and said,Claims that CBG is a miracle drug should be avoided. While new and exciting, replication and additional research is essential."The study also includes a number of studies to determine the effects of CBG on menopausal symptoms.

It is also an information dissemination organization for cannabinoid medicine.Realm of Caring (USA)In a 2026 review,Although CBG and CBGA have shown significant biological activity at the animal and cellular levels, there is still little data available on humans. Transparent and rigorous research will determine the future of cannabinoid acceptance in society." he pointed out,The importance of providing honest information to consumersis emphasized.

The main forms of CBG and how to choose

CBG products have appeared on the market in various forms in recent years, and choosing the form that's right for you is the first step in incorporating CBG into your daily routine.

When choosing a product, we recommend checking the following points:

• COA (Certificate of Analysis / Third-Party Inspection Certificate)Is it published?
• Has it been proven that the THC content is below the legal limit?
• Are they tested for pesticide, heavy metal and solvent residues?
• Is the CBG content (mg) clearly displayed?

What's the Difference Between CBG and CBD? - How to Choose Them

CBGwithCBDIn commonnon-psychoactiveandAnti-inflammatory propertiesHowever, due to differences in molecular structure, research has shown that they have different directions of action.

Of particular note is its effect on appetite, according to preliminary research.CBG is an appetite stimulantIt is likely thatCBD is an appetite suppressant(However, further research is needed.) Also, in the 2024 WSU clinical trial,CBG has the same anti-anxiety effect as CBD at a dose of about 5%It has also been reported that the efficiency of the system is significantly improved.

In addition, when CBG and CBD are combined,"Entourage Effect"It has also been suggested that multiple cannabinoids and terpenes may work together to produce greater effects than either of them used alone through a so-called synergistic effect, a concept discussed in detail by Dr. Ethan Russo in his 2011 study, "Taming THC."

Legal Status of CBG (Regulations in Japan)

As of January 2024, CBG is not regulated in Japan.The Cannabis Control Act and the Narcotics and Psychotropic Substances Control Act primarily regulate psychoactive ingredients such as THC (tetrahydrocannabinol).Non-psychoactive CBG can currently be legally distributed, sold, and used in products that do not contain THC..

However, the law is subject to change,Always check the latest legal informationWe recommend that you alsoTHC-free product certified with COAplease choose.